SS-31 – Mitochondria-Targeted Antioxidant Peptide

SS-31 50 mg (also known as Elamipretide / MTP-131 / Bendavia) is a cell-permeable tetrapeptide engineered to localize to the inner mitochondrial membrane where it binds cardiolipin, stabilizes cristae structure, and optimizes electron transport chain (ETC) function. By reducing mitochondrial reactive oxygen species (ROS) and improving ATP production, SS-31 is widely used in research on ischemia–reperfusion injury, heart failure, skeletal muscle fatigue, kidney injury, and neurodegenerative disorders.

Key Features & Research Applications

⚡ Mitochondrial Optimization
Stabilizes cardiolipin–ETC interactions to enhance oxidative phosphorylation and ATP output.

🛡️ Targeted Antioxidant
Selectively reduces mitochondrial ROS and prevents lipid peroxidation without broadly suppressing redox signaling.

❤️ Cardio- & Renoprotective Studies
Evaluated in models of myocardial ischemia, heart failure, and acute kidney injury for improved bioenergetics and tissue survival.

💪 Skeletal Muscle & Fatigue
Improves mitochondrial efficiency, endurance, and recovery in muscle performance research.

🧠 Neuroprotection
Explored in optic/retinal and neurodegenerative models (e.g., LHON, Parkinsonian paradigms) for mitochondrial rescue.

Product Details

• Name: SS-31 (Elamipretide, MTP-131, Bendavia)

• Form: Lyophilized powder

• Sequence (tetrapeptide): D-Arg–(2′,6′-dimethyl)Tyr–Lys–Phe–NH₂

• Peptide Class: Aromatic-cationic, mitochondria-targeting tetrapeptide

• Molecular Weight: ~639.8 Da

• Purity: ≥ 98% (HPLC verified)

• Dosage Strength: 50 mg per vial

• Appearance: White to off-white lyophilized powder

• Solubility: Sterile water or mild aqueous buffers (e.g., PBS); gentle mixing recommended

• Storage: Store dry at 35.6–46.4°F; after reconstitution, aliquot and freeze (−4°F); avoid repeated freeze–thaw

• Packaging: Sterile, sealed research-grade vial

• Verification: Third-party tested for identity and purity