Description
FST-344 – Myostatin/Activin-Binding Muscle Research Protein
FST-344 1 mg (Follistatin-344) is a recombinant follistatin isoform engineered for high-affinity binding to myostatin (GDF-8) and activins (e.g., Activin A). By sequestering these TGF-β superfamily ligands, FST-344 releases inhibition on muscle growth, modulates inflammation/fibrosis signaling, and supports studies of skeletal muscle hypertrophy, regeneration, and metabolic health.
Key Features & Research Applications
💪 Myostatin Inhibition
Neutralizes myostatin to de-repress muscle protein synthesis and satellite-cell activity.
🧬 Activin/TGF-β Pathway Modulation
Binds activins to rebalance SMAD signaling involved in muscle, fertility, and tissue remodeling.
🩹 Muscle Repair & Regeneration
Evaluated in models of injury, sarcopenia, cachexia, and performance recovery.
🛡️ Anti-Fibrotic & Anti-Inflammatory Signaling
Downstream effects may reduce fibrotic remodeling in muscle and other tissues.
⚙️ Combination Research
Often studied alongside GH/IGF-1 axis modulators, resistance training paradigms, or ECM-targeting peptides.
Product Details
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Name: Follistatin-344 (FST-344)
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Class: Recombinant binding protein (TGF-β ligand trap)
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Form: Lyophilized powder (research grade)
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Length/Size: 344-aa isoform (unglycosylated mass ~39 kDa; glycosylation may increase apparent mass)
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Purity: ≥ 95–98% (SDS-PAGE/HPLC, lot-dependent)
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Dosage Strength: 1 mg per vial
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Appearance: White to off-white lyophilized cake or powder
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Solubility: Sterile water or buffered saline; add gently with slow swirling—avoid foaming
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Storage (dry): 35.6–46.4°F; for long term, −4°F protected from moisture/light
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Storage (reconstituted): Aliquot and freeze at −4°F; avoid repeated freeze–thaw cycles
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Endotoxin: Research-grade specification (EU/mg lot-dependent)
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Packaging: Sterile, sealed vial with tamper-evident closure
