Description
IGF-1 LR3 – Long-Acting Insulin-Like Growth Factor Research Peptide
IGF-1 LR3 1 mg (Insulin-Like Growth Factor-1 Long R3) is a synthetic, bioengineered variant of human IGF-1, modified to enhance its biological activity and half-life. The substitution of arginine at position 3 (R3) and an extended 13-amino-acid N-terminal sequence significantly reduces its binding affinity to IGF-binding proteins (IGFBPs) — allowing more IGF-1 to remain bioavailable for receptor activation.
IGF-1 LR3 is widely studied for its effects on cell growth, muscle regeneration, neuroprotection, and metabolic regulation through its strong activation of the IGF-1 receptor (IGF-1R) and downstream PI3K/Akt signaling.
Key Features & Research Applications
💪 Muscle Growth & Regeneration:
Promotes satellite cell activation, muscle fiber repair, and hypertrophy in muscle research models.
🧬 Extended Activity:
Modified structure provides a longer half-life (≈ 20–30 hours vs. ~20 minutes for native IGF-1), supporting sustained receptor activation.
⚡ Anabolic & Recovery Studies:
Enhances protein synthesis, nutrient uptake, and recovery following cellular stress or injury.
🧠 Neuroprotective Effects:
Investigated for supporting neuron survival, plasticity, and protection from oxidative or metabolic damage.
🔥 Metabolic & Longevity Research:
Supports glucose metabolism, insulin sensitivity, and mitochondrial function, linking to anti-aging mechanisms.
Product Details
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Name: IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor-1)
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Form: Lyophilized powder
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Sequence: 83 amino acids (13 additional at N-terminus + Arg substitution at position 3)
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Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₂₀S₉
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Molecular Weight: ~9,200 Da
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Purity: ≥ 98% (HPLC verified)
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Dosage Strength: 1 mg per vial
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Appearance: White to off-white lyophilized powder
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Storage: Store at 35.6–46.4°F; after reconstitution, aliquot and freeze (−4°F); avoid repeated freeze–thaw cycles.
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Solubility: Sterile water or bacteriostatic saline; gentle mixing recommended.
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Packaging: Sterile, sealed research-grade vial
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Verification: Third-party tested for purity, sequence, and biological activity
